Cannabinoid Research on Safety/Toxicology in Animals
35 studies indexed
We have indexed 35 peer-reviewed studies examining cannabinoids (CBD, CBG and related compounds) in the context of safety/toxicology in animals. Below is the evidence, newest first, each linked to its source on PubMed. Evidence quality varies by study — this is a reference index, not medical advice.
A cell-based Sonic Hedgehog signaling transduction system to identify additive and synergistic chemical interactions
Beames TG, Everson JL, Desai DA et al. · Toxicol Sci · Year 2026 · Species: Zebrafish
View on PubMed →Hemp inflorescence meal as a novel feed ingredient in laying hens: Safety assessment, nutritional characterization, and effects on egg quality
Saengsuwan H, Bunchasak C, Rakangthong C et al. · Vet World · Year 2025 · Species: Bird
View on PubMed →Dietary Cannabidiol Supplementation on Growth Performance, Behavior, Blood Profile, Metabolomic Analysis, and Fatty Acid Composition in Rabbits: A Multi-Disciplinary Approach to Improve Welfare and Productivity
Addeo NF, Iervolino V, Amato R et al. · Vet Sci · Year 2025 · Species: Rabbit
View on PubMed →Pharmaceutical exposure and toxicosis in dogs: A retrospective study of 223 cases from a Canadian veterinary teaching hospital (2018 to 2023)
Kennedy J, Chicoine A, Loewen J et al. · Can Vet J · Year 2025 · Species: Dog
View on PubMed →Tissue residue depletion of cannabinoids in cattle administered industrial hemp inflorescence
Fritz BR, Kleinhenz MD, Magnin G et al. · Sci Rep · Year 2025 · Species: Cattle
View on PubMed →Comparison of clinicopathologic findings and urine drug screen results in cannabis-positive and control dogs
Pereira HCDS, Barbosa WMB, Venceslau MF et al. · Front Vet Sci · Year 2025 · Species: Dog
View on PubMed →Severe Cannabinoid Intoxication in a Ferret (Mustela putorius furo) Treated With Intravenous Lipid Emulsion
Huerta C, Lamarca A, Lam WYE et al. · J Vet Emerg Crit Care (San Antonio) · Year 2025 · Species: Ferret
View on PubMed →Corrigendum to "Safety assessment of female sexual hygiene product containing cannabidiol in New Zealand white rabbit and clinical trial" [Toxicol. Rep. 13 (2024) 101692]
Kamudhamas A, Muengtaweepongsa S, Bunman S et al. · Toxicol Rep · Year 2024 · Species: Rabbit
View on PubMed →Dog and cat exposures to drugs of abuse identified by the California animal health and food safety laboratory system 2013-2023
Klainbart S, Sykes CA, Poppenga RH. · Front Vet Sci · Year 2024 · Species: Cat, Dog
View on PubMed →Phytotherapeutic Approaches in Canine Pediatrics
Quintavalla F. · Vet Sci · Year 2024 · Species: Dog
View on PubMed →Flumazenil may improve gait and mentation in dogs presenting with marijuana toxicosis
Fitzgerald AH, Zhang Y, Stewart S et al. · Front Vet Sci · Year 2024 · Species: Dog
View on PubMed →Screening System of Cannabis sativa Extracts Based on Their Mitochondrial Safety Profile Using Cytochrome c Oxidase Activity as a Biomarker
Noskova E, Fernández R, García J et al. · Int J Mol Sci · Year 2023 · Species: Cattle
View on PubMed →Evaluation of an Oral Supplemental Cannabidiol Product for Acceptability and Performance in Mature Horses
Leise JM, Leatherwood JL, Paris BL et al. · Animals (Basel) · Year 2023 · Species: Horse
View on PubMed →Aqueous cannabidiol β-cyclodextrin complexed polymeric micelle nasal spray to attenuate in vitro and ex vivo SARS-CoV-2-induced cytokine storms
Changsan N, Sawatdee S, Suedee R et al. · Int J Pharm · Year 2023 · Species: Pig
View on PubMed →Simple and fast quantification of cannabinoids in animal feeds by liquid chromatography-tandem mass spectrometry
Xu X, Murphy LA. · J Vet Diagn Invest · Year 2023 · Species: Cattle
View on PubMed →Digital Technologies Applied to Control the One-Step Process of Cannabis Olive Oil Preparations
Bongiorno P, Lopalco A, Casiraghi A et al. · Pharmaceutics · Year 2023 · Species: Zebrafish
View on PubMed →Comparing the diagnostic performance of ordinary, mixed, and lasso logistic regression models at identifying opioid and cannabinoid poisoning in U.S. dogs using pet demographic and clinical data reported to an animal poison control center (2005-2014)
Howard-Azzeh M, Pearl DL, O'Sullivan TL et al. · PLoS One · Year 2023 · Species: Dog
View on PubMed →Intoxication of dogs and cats with common stimulating, hallucinogenic and dissociative recreational drugs
Oster E, Čudina N, Pavasović H et al. · Vet Anim Sci · Year 2023 · Species: Cat, Dog
View on PubMed →Can North American animal poison control center call data provide early warning of outbreaks associated with contaminated pet food? Using the 2007 melamine pet food contamination incident as a case study
Swirski AL, Pearl DL, Berke O et al. · PLoS One · Year 2022 · Species: Cat, Dog
View on PubMed →Examining the differential use of a North American animal poison control call center by veterinarians and the public for dog-related calls
Shahin K, Pearl DL, Martinko C et al. · PLoS One · Year 2022 · Species: Dog
View on PubMed →Spatial, temporal, and space-time clusters associated with opioid and cannabis poisoning events in U.S. dogs (2005-2014)
Howard-Azzeh M, Pearl DL, Berke O et al. · PLoS One · Year 2022 · Species: Dog
View on PubMed →Prevalence and characteristics of cannabis-induced toxicoses in pets: Results from a survey of veterinarians in North America
Amissah RQ, Vogt NA, Chen C et al. · PLoS One · Year 2022 · Species: Dog
View on PubMed →Long-term daily feeding of cannabidiol is well-tolerated by healthy dogs
Bradley S, Young S, Bakke AM et al. · Front Vet Sci · Year 2022 · Species: Dog
View on PubMed →The impact of state cannabis legislation, county-level socioeconomic and dog-level characteristics on reported cannabis poisonings of companion dogs in the USA (2009-2014)
Howard-Azzeh M, Pearl DL, Swirski A et al. · PLoS One · Year 2021 · Species: Dog
View on PubMed →Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and Δ(9)-tetrahydrocannabinol
Kanyo R, Amin MR, Locskai LF et al. · Sci Rep · Year 2021 · Species: Zebrafish
View on PubMed →Transcriptomic Changes and the Roles of Cannabinoid Receptors and PPARγ in Developmental Toxicities Following Exposure to Δ9-Tetrahydrocannabinol and Cannabidiol
Pandelides Z, Aluru N, Thornton C et al. · Toxicol Sci · Year 2021 · Species: Zebrafish
View on PubMed →Detecting and quantifying marijuana metabolites in serum and urine of 19 dogs affected by marijuana toxicity
Fitzgerald AH, Zhang Y, Fritz S et al. · J Vet Diagn Invest · Year 2021 · Species: Dog
View on PubMed →In Vivo Evaluation of Cannabis sativa Full Extract on Zebrafish Larvae Development, Locomotion Behavior and Gene Expression
Licitra R, Martinelli M, Petrocchi Jasinski L et al. · Pharmaceuticals (Basel) · Year 2021 · Species: Zebrafish
View on PubMed →Assessing the bioactivity of cannabis extracts in larval zebrafish
Nixon J, Abramovici H, Cabecinha A et al. · J Cannabis Res · Year 2021 · Species: Zebrafish
View on PubMed →The identification of risk factors contributing to accidental opioid poisonings in companion dogs using data from a North American poison control center (2006-2014)
Howard-Azzeh M, Pearl DL, O'Sullivan TL et al. · PLoS One · Year 2020 · Species: Dog
View on PubMed →Comparing the prevalence of tetrahydrocannabinol (THC) toxicities in dogs before and after legalization of cannabis in Canada
Joffe M, Joffe D. · Can Vet J · Year 2020 · Species: Dog
View on PubMed →Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio)
Pandelides Z, Thornton C, Faruque AS et al. · Geroscience · Year 2020 · Species: Zebrafish
View on PubMed →Toxicity Assessment of Herbal Medicine Using Zebrafish Embryos: A Systematic Review
Jayasinghe CD, Jayawardena UA. · Evid Based Complement Alternat Med · Year 2019 · Species: Mouse, Rabbit, Rat, Zebrafish
View on PubMed →Fatal diphenhydramine poisoning in a dog
Buchweitz JP, Raverty SA, Johnson MB et al. · Can Vet J · Year 2014 · Species: Dog
View on PubMed →In vitro metabolism and metabolic effects of ajulemic acid, a synthetic cannabinoid agonist
Burstein SH, Tepper MA. · Pharmacol Res Perspect · Year 2013 · Species: Dog, Rat
View on PubMed →
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