Cannabinoid Research on Pain/Arthritis in Animals
73 studies indexed
We have indexed 73 peer-reviewed studies examining cannabinoids (CBD, CBG and related compounds) in the context of pain/arthritis in animals. Below is the evidence, newest first, each linked to its source on PubMed. Evidence quality varies by study — this is a reference index, not medical advice.
Efficacy, pharmacokinetics and safety of liposomal synthetic cannabidiol injected subcutaneously in dogs: a randomized, blinded, placebo-controlled, crossover clinical trial
Shilo-Benjamini Y, Milgram J, Lavy E et al. · Front Vet Sci · Year 2026 · Species: Dog
View on PubMed →Correction: Cannabis-based extract for managing pain in dogs with osteoarthritis: efficacy and safety assessment
Griebeler NM, Penayo Cremonese R, Correa YRF et al. · Front Pharmacol · Year 2026 · Species: Dog
View on PubMed →Randomized and Blind Evaluation of the Efficacy of a Full-Spectrum Oral Cannabis sativa Oil Extract, Standardized Based on CBD-A, CBD and THC-A, THC in Canines with Chronic Osteoarthritis
Benjamin ET, Maria Teresa SE, Alexander NS et al. · Animals (Basel) · Year 2026 · Species: Dog
View on PubMed →Overview of the Current Osteoarthritis Treatment in Veterinary Medicine and Future Directions
Quintão NLM, Moffa EB, Kroier M et al. · ACS Pharmacol Transl Sci · Year 2026 · Species: Cat, Dog, Horse
View on PubMed →Plant-Derived Functional Ingredients in Pet Nutrition: Phytochemical Classification, Mechanisms, Efficacy, and Application in Dogs and Cats
Srisa A, Kamonpatana P, Promhuad K et al. · Animals (Basel) · Year 2026 · Species: Cat, Dog
View on PubMed →Effects of spray-dried animal plasma on inflammatory indicators, antioxidant capacity, and joint health in senior dogs
Sun Z, Campbell J, Polo J et al. · J Anim Sci · Year 2026 · Species: Dog
View on PubMed →Liposomal-synthetic-cannabidiol: preliminary translational evidence of efficacy, tolerability and pharmacokinetics following repeated subcutaneous injections in two goats
Shilo-Benjamini Y, Abu Ahmad W, Barasch D et al. · Front Pharmacol · Year 2025 · Species: Dog, Goat
View on PubMed →Cannabis-based extract for managing pain in dogs with osteoarthritis: efficacy and safety assessment
Griebeler NM, Cremonese RP, Fakih Correa YR et al. · Front Pharmacol · Year 2025 · Species: Dog
View on PubMed →Pain and pain management in cats: an ever-evolving field
Epstein ME. · J Feline Med Surg · Year 2025 · Species: Cat
View on PubMed →Priming Canine Adipose Tissue-Derived Mesenchymal Stem Cells with CBD-Rich Cannabis Extract Modulates Neurotrophic Factors Expression Profile
Perino VS, Ferreira LVO, Kamura BDC et al. · Vet Sci · Year 2025 · Species: Cat, Dog
View on PubMed →Cannabinoid and cannabinoid related receptors in fibroblasts, inflammatory and endothelial cells of the equine hoof with and without laminitis: novel pharmacological target
Zamith Cunha R, Gobbo F, Morini M et al. · Front Vet Sci · Year 2025 · Species: Horse
View on PubMed →Cytotoxicity of Cannabinoids in Combination with Traditional Lymphoma Chemotherapeutic Drugs Against Non-Hodgkin's Lymphoma
Omer S, Mansour M, Pondugula SR et al. · Biomedicines · Year 2025 · Species: Dog
View on PubMed →The pro-, but not anti-nociceptive effects of Cannabidiol depend on Trpa1b in larval Zebrafish
Lecamp B, Bianucci Q, Rauniyar S et al. · bioRxiv · Year 2025 · Species: Zebrafish
View on PubMed →Pharmacokinetics of a single oral administration of two cannabidiol formulations in fed and fasted horses
Di Salvo A, Bazzano M, Rocca GD et al. · Front Vet Sci · Year 2025 · Species: Horse
View on PubMed →Does oral cannabidiol oil in adjunct to pain medications help reduce pain and improve locomotion in dogs with osteoarthritis?
Yeung T, Uquillas E. · Vet Evid · Year 2025 · Species: Dog
View on PubMed →Efficacy of a 20:1 CBD:THC cannabis herbal extract for pain and inflammation in dogs following tibial plateau leveling osteotomy
Lyons C, Pinto KR, Penney K et al. · Front Vet Sci · Year 2025 · Species: Dog
View on PubMed →Exploring Cannabinoid Effects Using Zebrafish (Danio rerio) as an In Vivo Model: A Review of the Literature
Wang X, Xie H, Shi X et al. · Int J Mol Sci · Year 2025 · Species: Zebrafish
View on PubMed →Incorporating a Behavioral Medicine Approach in the Multi-Modal Management of Chronic Equine Gastric Ulcer Syndrome (EGUS): A Clinical Commentary
Klinck M, Lovett A, Sykes B. · Animals (Basel) · Year 2025 · Species: Horse
View on PubMed →Feline chronic pain management: the importance of a team approach for optimal outcomes
Monteiro BP, Taylor S, Dowgray N et al. · J Feline Med Surg · Year 2025 · Species: Cat
View on PubMed →Translational validity of quantitative sensory testing in chronic pain neuro-sensitization: guide of use and interpretation in osteoarthritis animal models
Frézier M, Delsart A, Lefort-Holguin M et al. · Front Pain Res (Lausanne) · Year 2025 · Species: Cat, Dog, Rat
View on PubMed →Field safety and efficacy study with a cannabidiol/cannabidiol acid-rich hemp paste in cats with osteoarthritic pain
Mulder LM, Deterd Oude Weme J, Blees NR et al. · J Feline Med Surg · Year 2025 · Species: Cat
View on PubMed →The Effectiveness of Amitriptyline and Gabapentin in Treating Pomeranians with Chiari-like Malformation and/or Syringomyelia
Maat RT, Heusden KV, Hoogervorst-Spek L et al. · Animals (Basel) · Year 2025 · Species: Dog
View on PubMed →Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners
Wang AYL, Aviña AE, Liu YY et al. · Front Vet Sci · Year 2025 · Species: Dog
View on PubMed →Evaluation of Cannabidiol Oil's Effects on Sedation, Behavioral Responses to Handling, and Nociceptive Thresholds in Healthy Cats
Wanapinit K, Niyom S, Suriyawongpongsa P et al. · Animals (Basel) · Year 2025 · Species: Cat
View on PubMed →Psychedelics as Novel Therapeutics for Chronic Pain in Veterinary Medicine: A Hypothesis-Driven Protocol Using Low-Dose 1-Cyclopropionyl-D-lysergic Acid Diethylamide (1cp-LSD) in Canine Osteoarthritis
Hernández-Álvarez E, Acosta-Dacal A, Luzardo OP et al. · Animals (Basel) · Year 2025 · Species: Dog
View on PubMed →A proposed framework for practical multimodal management of osteoarthritis in growing dogs
Marcellin-Little DJ, Hulse DA, Huntingford JL et al. · Front Vet Sci · Year 2025 · Species: Dog
View on PubMed →Assessing Facial Thermal Nociceptive Response in Female Dogs After Elective Ovariohysterectomy Anesthetized with Isoflurane and Treated with Cannabidiol and Meloxicam Analgesia
Casas-Alvarado A, Mora-Medina P, Hernández-Avalos I et al. · Animals (Basel) · Year 2025 · Species: Dog
View on PubMed →The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols
McGrath S, Hull E, Dunbar MD et al. · Alzheimers Dement · Year 2025 · Species: Dog
View on PubMed →Efficacy and tolerability of full spectrum hemp oil in dogs living with pain in common household settings
Panda C, Rathinasabapathy T, Metzger B et al. · Front Vet Sci · Year 2024 · Species: Dog
View on PubMed →Comparison of grapiprant and meloxicam for management of postoperative joint pain in dogs: A randomized, double-blinded, prospective clinical trial
Cassemiche A, Schoffit S, Manassero M et al. · J Vet Intern Med · Year 2024 · Species: Dog
View on PubMed →Use of Bedinvetmab (Librela(®)) for Canine Osteoarthritis in France, Germany, Italy, Spain, and the UK: Quantitative Analysis of Veterinarian Satisfaction and Real-World Treatment Patterns
Gildea E, North C, Walker K et al. · Animals (Basel) · Year 2024 · Species: Dog
View on PubMed →Perioperative Analgesic and Sedative Effects of Cannabidiol in Cats Undergoing Ovariohysterectomy
Zanelli GR, Vieira GBM, Souza RVM et al. · Animals (Basel) · Year 2024 · Species: Cat
View on PubMed →Evaluation of the effect of cannabidiol administration with and without nonsteroidal anti-inflammatory drugs in dogs with mobility disorders: a prospective, double-blind, crossover, placebo-controlled study
Talsma B, Elam LH, McGrath S et al. · Front Vet Sci · Year 2024 · Species: Dog
View on PubMed →The therapeutic effectiveness of oral cannabidiol in addition to current treatment in cats with osteoarthritis
Wilkinson O. · Vet Evid · Year 2024 · Species: Cat
View on PubMed →The oral intake of specific Bioactive Collagen Peptides (BCP) improves gait and quality of life in canine osteoarthritis patients-A translational large animal model for a nutritional therapy option
Dobenecker B, Böswald LF, Reese S et al. · PLoS One · Year 2024 · Species: Dog
View on PubMed →Neuropathic pain in cats: Mechanisms and multimodal management
Rusbridge C. · J Feline Med Surg · Year 2024 · Species: Cat
View on PubMed →Assessment of the nociceptive response to the use of cannabidiol alone and in combination with meloxicam through infrared pupillometry in female dogs undergoing elective ovariohysterectomy
Casas-Alvarado A, Martínez-Burnes J, Hernández-Ávalos I et al. · Front Vet Sci · Year 2024 · Species: Dog
View on PubMed →Danish dog owners' use and the perceived effect of unlicensed cannabis products in dogs
Holst P, Kristensen AT, Arendt ML. · PLoS One · Year 2024 · Species: Dog
View on PubMed →Role of cannabidiolic acid or the combination of cannabigerol/cannabidiol in pain modulation and welfare improvement in horses with chronic osteoarthritis
Aragona F, Tabbì M, Gugliandolo E et al. · Front Vet Sci · Year 2024 · Species: Horse
View on PubMed →Film Forming Systems for Delivery of Active Molecules into and across the Skin
Touitou E, Natsheh H, Zailer J. · Pharmaceutics · Year 2023 · Species: Mouse, Pig
View on PubMed →A case report of CBD and THC as analgesic therapy in a cat with chronic osteoarthritic pain
Gutierre E, Crosignani N, García-Carnelli C et al. · Vet Med Sci · Year 2023 · Species: Cat
View on PubMed →Therapeutic efficacy and pharmacokinetics of liposomal-cannabidiol injection: a pilot clinical study in dogs with naturally-occurring osteoarthritis
Shilo-Benjamini Y, Lavy E, Yair N et al. · Front Vet Sci · Year 2023 · Species: Dog
View on PubMed →Evaluation of the efficacy of a cannabidiol and cannabidiolic acid rich hemp extract for pain in dogs following a tibial plateau leveling osteotomy
Klatzkow S, Davis G, Shmalberg J et al. · Front Vet Sci · Year 2023 · Species: Dog
View on PubMed →Expression of cannabinoid (CB1 and CB2) and cannabinoid-related receptors (TRPV1, GPR55, and PPARα) in the synovial membrane of the horse metacarpophalangeal joint
Zamith Cunha R, Zannoni A, Salamanca G et al. · Front Vet Sci · Year 2023 · Species: Horse
View on PubMed →Canine immune cells express high levels of CB(1) and CB(2) cannabinoid receptors and cannabinoid-mediated alteration of canine cytokine production is vehicle-dependent
Brown C, Mitsch M, Blankenship K et al. · Vet Immunol Immunopathol · Year 2023 · Species: Dog
View on PubMed →Endocannabinoid System Receptors at the Hip and Stifle Joints of Middle-Aged Dogs: A Novel Target for the Therapeutic Use of Cannabis sativa Extract in Canine Arthropathies
Zamith Cunha R, Salamanca G, Mille F et al. · Animals (Basel) · Year 2023 · Species: Dog
View on PubMed →The Clinical Pharmacology and Therapeutic Evaluation of Non-Steroidal Anti-Inflammatory Drugs in Adult Horses
Mercer MA, Davis JL, McKenzie HC. · Animals (Basel) · Year 2023 · Species: Horse
View on PubMed →An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics
Alini M, Diwan AD, Erwin WM et al. · JOR Spine · Year 2023 · Species: Dog, Horse, Mouse, Sheep
View on PubMed →Efficient controlled release of cannabinoids loaded in γ-CD-MOFs and DPPC liposomes as novel delivery systems in oral health
Rodríguez-Martínez J, Sánchez-Martín MJ, Valiente M. · Mikrochim Acta · Year 2023 · Species: Cattle
View on PubMed →COAST Development Group's international consensus guidelines for the treatment of canine osteoarthritis
Cachon T, Frykman O, Innes JF et al. · Front Vet Sci · Year 2023 · Species: Dog
View on PubMed →Management of Osteoarthritis and Joint Support Using Feed Supplements: A Scoping Review of Undenatured Type II Collagen and Boswellia serrata
Zapata A, Fernández-Parra R. · Animals (Basel) · Year 2023 · Species: Dog
View on PubMed →Efficacy and safety of cannabidiol for the treatment of canine osteoarthritis: a systematic review and meta-analysis of animal intervention studies
Patikorn C, Nerapusee O, Soontornvipart K et al. · Front Vet Sci · Year 2023 · Species: Dog
View on PubMed →Placebo-Controlled Trial of Daily Oral Cannabidiol as Adjunctive Treatment for Cats with Chronic Gingivostomatitis
Coelho JC, Duarte N, Bento da Silva A et al. · Animals (Basel) · Year 2023 · Species: Cat
View on PubMed →Effects of low-level laser therapy on impaired mobility in dogs with naturally occurring osteoarthritis
Barale L, Monticelli P, Adami C. · Vet Med Sci · Year 2023 · Species: Dog
View on PubMed →Advances in the pharmaceutical treatment options for canine osteoarthritis
Pye C, Bruniges N, Peffers M et al. · J Small Anim Pract · Year 2022 · Species: Dog
View on PubMed →Dietary supplementation of hemp oil in teddy dogs: Effect on apparent nutrient digestibility, blood biochemistry and metabolomics
Xin G, Yang J, Li R et al. · Bioengineered · Year 2022 · Species: Dog
View on PubMed →Proposed Canadian Consensus Guidelines on Osteoarthritis Treatment Based on OA-COAST Stages 1-4
Mosley C, Edwards T, Romano L et al. · Front Vet Sci · Year 2022 · Species: Dog
View on PubMed →The effect of a mixed cannabidiol and cannabidiolic acid based oil on client-owned dogs with atopic dermatitis
Loewinger M, Wakshlag JJ, Bowden D et al. · Vet Dermatol · Year 2022 · Species: Dog
View on PubMed →A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis
Barbeau-Grégoire M, Otis C, Cournoyer A et al. · Int J Mol Sci · Year 2022 · Species: Cat, Dog
View on PubMed →A Case Report of Subcutaneously Injected Liposomal Cannabidiol Formulation Used as a Compassion Therapy for Pain Management in a Dog
Shilo-Benjamini Y, Cern A, Zilbersheid D et al. · Front Vet Sci · Year 2022 · Species: Dog
View on PubMed →2022 ISFM Consensus Guidelines on the Management of Acute Pain in Cats
Steagall PV, Robertson S, Simon B et al. · J Feline Med Surg · Year 2022 · Species: Cat
View on PubMed →Cellular distribution of cannabinoid-related receptors TRPV1, PPAR-gamma, GPR55 and GPR3 in the equine cervical dorsal root ganglia
Galiazzo G, De Silva M, Giancola F et al. · Equine Vet J · Year 2021 · Species: Horse
View on PubMed →Expression of cannabinoid and cannabinoid-related receptors in the oral mucosa of healthy cats and cats with chronic gingivostomatitis
Polidoro G, Galiazzo G, Giancola F et al. · J Feline Med Surg · Year 2021 · Species: Cat
View on PubMed →Cannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum
Toschi A, Galiazzo G, Piva A et al. · Animals (Basel) · Year 2021 · Species: Pig
View on PubMed →Dose-Related Inhibition of Capsaicin Responses by Cannabinoids CBG, CBD, THC and their Combination in Cultured Sensory Neurons
Anand U, Oldfield C, Pacchetti B et al. · J Pain Res · Year 2021 · Species: Cattle, Rat
View on PubMed →Oral Transmucosal Cannabidiol Oil Formulation as Part of a Multimodal Analgesic Regimen: Effects on Pain Relief and Quality of Life Improvement in Dogs Affected by Spontaneous Osteoarthritis
Brioschi FA, Di Cesare F, Gioeni D et al. · Animals (Basel) · Year 2020 · Species: Dog
View on PubMed →Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders
Fernández-Trapero M, Pérez-Díaz C, Espejo-Porras F et al. · Biomolecules · Year 2020 · Species: Dog
View on PubMed →Motivations and expectations for using cannabis products to treat pain in humans and dogs: a mixed methods study
Wallace JE, Kogan LR, Carr ECJ et al. · J Cannabis Res · Year 2020 · Species: Dog
View on PubMed →Cellular Distribution of Canonical and Putative Cannabinoid Receptors in Canine Cervical Dorsal Root Ganglia
Chiocchetti R, Galiazzo G, Tagliavia C et al. · Front Vet Sci · Year 2019 · Species: Dog
View on PubMed →Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs
Gamble LJ, Boesch JM, Frye CW et al. · Front Vet Sci · Year 2018 · Species: Dog
View on PubMed →Intraocular pressure-lowering effect of oral paracetamol and its in vitro corneal penetration properties
Mohamed N, Meyer D. · Clin Ophthalmol · Year 2013 · Species: Rabbit
View on PubMed →Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity
Dirikoc S, Priola SA, Marella M et al. · J Neurosci · Year 2007 · Species: Mouse, Sheep
View on PubMed →The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
Malfait AM, Gallily R, Sumariwalla PF et al. · Proc Natl Acad Sci U S A · Year 2000 · Species: Cattle, Mouse
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