Cannabinoid Research on Anxiety/Stress in Animals
63 studies indexed
We have indexed 63 peer-reviewed studies examining cannabinoids (CBD, CBG and related compounds) in the context of anxiety/stress in animals. Below is the evidence, newest first, each linked to its source on PubMed. Evidence quality varies by study — this is a reference index, not medical advice.
Development and Characterization of Dissolving Microneedles for the Buccal Delivery of Cannabidiol (CBD)
Paganopoulou E, Tzimtzimis E, Tzetzis D et al. · Micromachines (Basel) · Year 2026 · Species: Pig
View on PubMed →Fermented Plant-Derived Phytoconstituents in Biocosmetics: Pharmacological Enhancements and Applications
Suhaera S, Sammulia SF, Prayoga DK et al. · Clin Cosmet Investig Dermatol · Year 2026 · Species: Cat
View on PubMed →Evaluation of 1cp-LSD for Enhancing Welfare in Shelter Dogs: A Randomized Blind Trial with Ethological Intervention
Hernández-Álvarez E, Canino-Quijada C, Roiz S et al. · Vet Sci · Year 2026 · Species: Dog
View on PubMed →Owner-Directed Feline Aggression in Thailand: Characteristics, Associated Factors, and a Clinical Comparison of Treatments
Supanta J, Boonhoh W, Hayakijkosol O et al. · Life (Basel) · Year 2026 · Species: Cat
View on PubMed →Formulation-specific dose-response in the serum proteome of healthy dogs following cannabidiol administration
Theerapan W, Limsuwan S, Rattanasrisomporn J et al. · Front Vet Sci · Year 2026 · Species: Dog
View on PubMed →Cannabidiol Mitigates Deoxynivalenol-Induced Intestinal Toxicity by Regulating Inflammation, Oxidative Stress, and Barrier Integrity
Yang L, Decas T, Zhang Y et al. · Toxins (Basel) · Year 2025 · Species: Pig
View on PubMed →Expression of Concern: Masataka, N. Possible Anxiolytic Effects of Cannabidiol (CBD) Administration on Feline Responses to a Fear Response Test. Animals2025, 15, 1642
Animals Editorial Office. · Animals (Basel) · Year 2025 · Species: Cat
View on PubMed →Cannabinoid Receptors in the Horse Lateral Nucleus of the Amygdala: A Potential Target for Ameliorating Pain Perception, Stress and Anxiety in Horses
Bombardi C, Salamanca G, Tagliavia C et al. · Int J Mol Sci · Year 2025 · Species: Horse
View on PubMed →Pilot study: impacts of cannabinoids from industrial hemp and repeated transportation events on cattle health and immune status
Fritz BR, Kleinhenz MD, Griffin JJ et al. · Transl Anim Sci · Year 2025 · Species: Cattle
View on PubMed →A Preliminary Evaluation of the Comparative Efficacy of Gel-Based and Oil-Based CBD on Hematologic and Biochemical Responses in Dogs
Puttharaksa W, Charoensook R, Tungtrakanpoung R et al. · Vet Sci · Year 2025 · Species: Dog
View on PubMed →Cannabinoids Activate Endoplasmic Reticulum Stress Response and Promote the Death of Avian Retinal Müller Cells in Culture
Ventura ALM, Silva TM, França GR. · Brain Sci · Year 2025 · Species: Bird
View on PubMed →Effects of a Cannabinoid-Based Phytocomplex (Pain Relief(TM)) on Chronic Pain in Osteoarthritic Dogs
Amato R, Pacifico E, Lotito D et al. · Animals (Basel) · Year 2025 · Species: Dog
View on PubMed →Cannabidiol and nano-selenium mediate intestinal barrier function by affecting mucosal microstructures, and gut-associated immunological and oxidative stress response in the gut of chickens infected with C. perfringens
Szkopek D, Mendel M, Kinsner M et al. · Front Immunol · Year 2025 · Species: Bird
View on PubMed →Dose- and tissue-dependent effects of cannabidiol on antioxidant status in developing chicken embryos
Muchacka R. · Sci Rep · Year 2025 · Species: Bird
View on PubMed →Changes in the Activities of Antioxidant Enzymes in the Fat Body and Hemolymph of Apis mellifera L. Due to Pollen Monodiets
Bryś MS, Olszewski K, Bartoń M et al. · Antioxidants (Basel) · Year 2025 · Species: Cat
View on PubMed →Brief exposure to (-) THC affects zebrafish embryonic locomotion with effects that persist into the next generation
Amin MR, Khara L, Szaszkiewicz J et al. · Sci Rep · Year 2025 · Species: Zebrafish
View on PubMed →Comparative Analysis of Cannabidiol and Risperidone on Behavioral and Neurochemical Outcomes, and Neurodevelopment Markers in a Zebrafish Model of Embryonic Exposure to Sodium Valproate
Costa KCM, Brigante TAV, Lirio PHC et al. · Autism Res · Year 2025 · Species: Zebrafish
View on PubMed →Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study
Sacchettino L, Costanzo M, Veneruso I et al. · PLoS One · Year 2025 · Species: Dog
View on PubMed →Assessment of acute and chronic pain in canine internal medicine-what is missing in our diagnostic toolbox?
Sander AN, Storz S, Xenoulis PG et al. · Front Vet Sci · Year 2025 · Species: Dog
View on PubMed →Possible Anxiolytic Effects of Cannabidiol (CBD) Administration on Feline Responses to a Fear Response Test
Masataka N. · Animals (Basel) · Year 2025 · Species: Cat
View on PubMed →Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Felis catus) Using Three Pharmacological Models: Cannabidiol, Gabapentin, and Synthetic Facial Pheromones
Torres-Bernal F, Martínez-Burnes J, Hernández-Avalos I et al. · Vet Sci · Year 2025 · Species: Cat, Dog
View on PubMed →Treats containing cannabidiol, L-tryptophan and α-casozepine have a mild stress-reducing effect in dogs
Flint HE, Weller JE, Hunt ABG et al. · Front Vet Sci · Year 2025 · Species: Dog
View on PubMed →Evaluating the Potential of Microdosing 1cp-LSD for the Treatment of Canine Anxiety: A One-Month Case Study
Hernández-Álvarez E, Borkel LF, Rojas-Hernández J et al. · Vet Med Sci · Year 2025 · Species: Dog
View on PubMed →Tools for the Approach of Fear, Anxiety, and Stress in the Domestic Feline: An Update
Barrios F, Ruiz P, Damián JP. · Vet Med Int · Year 2025 · Species: Cat
View on PubMed →Nutraceuticals, Social Interaction, and Psychophysiological Influence on Pet Health and Well-Being: Focus on Dogs and Cats
Nicotra M, Iannitti T, Di Cerbo A. · Vet Sci · Year 2025 · Species: Cat, Dog
View on PubMed →Early Life Exposure to Δ(9)-Tetrahydrocannabinol Causes Persistent Growth, Behavior, and Bioenergetic Outcomes in Zebrafish
Pandelides Z, Thornton C, Paris JJ et al. · Cannabis Cannabinoid Res · Year 2025 · Species: Zebrafish
View on PubMed →Is cannabidiol (CBD) effective to ease separation anxiety?
Masataka N. · Heliyon · Year 2024 · Species: Cat
View on PubMed →Tolerability of 2 and 4 mg/kg Dosing Every 12 Hour of a Cannabidiol- and Cannabidiolic Acid-Rich Hemp Extract on Mixed-Breed Dogs Utilized for Teaching in a Closed Colony
Mills T, Myers S, Hughes D et al. · Animals (Basel) · Year 2024 · Species: Dog
View on PubMed →Behavioral observations, heart rate and cortisol monitoring in horses following multiple oral administrations of a cannabidiol containing paste (part 2/2)
Eichler F, Ehrle A, Machnik M et al. · Front Vet Sci · Year 2024 · Species: Horse
View on PubMed →Effects of Cannabidiol, ∆9-Tetrahydrocannabinol, and WIN 55-212-22 on the Viability of Canine and Human Non-Hodgkin Lymphoma Cell Lines
Omer S, Pathak S, Mansour M et al. · Biomolecules · Year 2024 · Species: Dog
View on PubMed →Impact of acute stress on the canine gut microbiota
Patel KV, Hunt ABG, Castillo-Fernandez J et al. · Sci Rep · Year 2024 · Species: Dog
View on PubMed →Interaction Between Peroxisome Proliferator-Activated Receptors and Cannabidiol in the Gut of Chickens Applied to Different Challenge Conditions
Szkopek D, Mendel M, Kinsner M et al. · Int J Mol Sci · Year 2024 · Species: Bird
View on PubMed →Behavioral, Physiological, and Pathological Approaches of Cortisol in Dogs
Mârza SM, Munteanu C, Papuc I et al. · Animals (Basel) · Year 2024 · Species: Dog
View on PubMed →Single-dose 1cp-LSD administration for canine anxiety: a pilot study
Henríquez-Hernández LA, García-Serrano I, Quintana-Hernández DJ et al. · Vet Res Commun · Year 2024 · Species: Dog
View on PubMed →Improved quality of life and pain relief in mature horses with osteoarthritis after oral transmucosal cannabidiol oil administration as part of an analgesic regimen
Interlandi C, Tabbì M, Di Pietro S et al. · Front Vet Sci · Year 2024 · Species: Horse
View on PubMed →Daily dosing of cannabidiol (CBD) demonstrates a positive effect on measures of stress in dogs during repeated exposure to car travel
Flint HE, Hunt ABG, Logan DW et al. · J Anim Sci · Year 2024 · Species: Dog
View on PubMed →Evaluation of indicators of acute emotional states in dogs
Flint HE, Weller JE, Parry-Howells N et al. · Sci Rep · Year 2024 · Species: Dog
View on PubMed →Investigating the effect a single dose of cannabidiol has on measures of stress in cats when being transported in a carrier and meeting a novel person in an unfamiliar environment
Weller JE, Flint HE, Hunt ABG et al. · Front Vet Sci · Year 2024 · Species: Cat
View on PubMed →Effects of Hemp-Derived Cannabidiol Supplementation on Blood Variables, Carcass Characteristics, and Meat Quality of Goats
Tathong T, Khamhan S, Soisungwan S et al. · Animals (Basel) · Year 2024 · Species: Goat
View on PubMed →Possible effects of cannabidiol (CBD) administration on the vocal activity of healthy domestic dogs upon their temporary separation from caregivers
Masataka N. · Heliyon · Year 2024 · Species: Dog
View on PubMed →Rough-set based learning: Assessing patterns and predictability of anxiety, depression, and sleep scores associated with the use of cannabinoid-based medicine during COVID-19
Ramanna S, Ashrafi N, Loster E et al. · Front Artif Intell · Year 2023 · Species: Cat
View on PubMed →Behavioral observations, heart rate and heart rate variability in horses following oral administration of a cannabidiol containing paste in three escalating doses (part 1/2)
Eichler F, Ehrle A, Jensen KC et al. · Front Vet Sci · Year 2023 · Species: Horse
View on PubMed →Pharmacokinetic modelling of orally administered cannabidiol and implications for medication control in horses
Eichler F, Poźniak B, Machnik M et al. · Front Vet Sci · Year 2023 · Species: Horse
View on PubMed →The Effects of Fresh Hemp Leaf Supplementation (Cannabis sativa) on the Physiological and Carcass Characteristics and Meat Quality in Transported Goats
Khamhan S, Tathong T, Phoemchalard C. · Animals (Basel) · Year 2023 · Species: Goat
View on PubMed →Remotely and collaboratively evaluating a campus-based therapy dog program during the COVID-19 pandemic
Fletcher-Hildebrand S, Williamson L, Lawson K et al. · Eval Program Plann · Year 2023 · Species: Dog
View on PubMed →A single dose of cannabidiol (CBD) positively influences measures of stress in dogs during separation and car travel
Hunt ABG, Flint HE, Logan DW et al. · Front Vet Sci · Year 2023 · Species: Dog
View on PubMed →Feline Stress Management During air Travel: A Multimodal Approach
Jahn K, DePorter T. · J Feline Med Surg · Year 2023 · Species: Cat
View on PubMed →Intraspecific Interactions Decrease Stress Affecting Welfare in Shelter Dogs: A Comparison of Four Different Housing Conditions
Corsetti S, Natoli E, Palme R et al. · Animals (Basel) · Year 2023 · Species: Dog
View on PubMed →Therapy and Prevention of Noise Fears in Dogs-A Review of the Current Evidence for Practitioners
Riemer S. · Animals (Basel) · Year 2023 · Species: Dog
View on PubMed →Ethanol Metabolism in the Liver, the Induction of Oxidant Stress, and the Antioxidant Defense System
Contreras-Zentella ML, Villalobos-García D, Hernández-Muñoz R. · Antioxidants (Basel) · Year 2022 · Species: Cat
View on PubMed →Essential Oils and Melatonin as Functional Ingredients in Dogs
Ruiz-Cano D, Sánchez-Carrasco G, El-Mihyaoui A et al. · Animals (Basel) · Year 2022 · Species: Dog
View on PubMed →Cannabidiol affects breast meat volatile compounds in chickens subjected to different infection models
Konieczka P, Wojtasik-Kalinowska I, Poltorak A et al. · Sci Rep · Year 2022 · Species: Bird
View on PubMed →Short term feeding of industrial hemp with a high cannabidiolic acid (CBDA) content increases lying behavior and reduces biomarkers of stress and inflammation in Holstein steers
Kleinhenz MD, Weeder M, Montgomery S et al. · Sci Rep · Year 2022 · Species: Cattle
View on PubMed →A Review on the Bioactivity of Cannabinoids on Zebrafish Models: Emphasis on Neurodevelopment
Licitra R, Marchese M, Naef V et al. · Biomedicines · Year 2022 · Species: Zebrafish
View on PubMed →Robust behavioural effects in response to acute, but not repeated, terpene administration in Zebrafish (Danio rerio)
Szaszkiewicz J, Leigh S, Hamilton TJ. · Sci Rep · Year 2021 · Species: Zebrafish
View on PubMed →The Effects of Cannabis sativa L. Extract on Oxidative Stress Markers In Vivo
Kubiliene A, Mickute K, Baranauskaite J et al. · Life (Basel) · Year 2021 · Species: Cat, Mouse
View on PubMed →Anxiety, depression-like behaviors and biochemistry disorders induced by cannabis extract in female mice
Mohammed AM, Khardali IA, Oraiby ME et al. · Saudi J Biol Sci · Year 2021 · Species: Cat, Mouse, Sheep
View on PubMed →Cannabis sativa L. may reduce aggressive behaviour towards humans in shelter dogs
Corsetti S, Borruso S, Malandrucco L et al. · Sci Rep · Year 2021 · Species: Dog
View on PubMed →The Impact of Feeding Cannabidiol (CBD) Containing Treats on Canine Response to a Noise-Induced Fear Response Test
Morris EM, Kitts-Morgan SE, Spangler DM et al. · Front Vet Sci · Year 2020 · Species: Dog
View on PubMed →Cannabinoid-mediated Modulation of Oxidative Stress and Early Inflammatory Response after Hypoxia-Ischemia
Alonso-Alconada D, Álvarez FJ, Goñi-de-Cerio F et al. · Int J Mol Sci · Year 2020 · Species: Sheep
View on PubMed →Canadian dog owners' use and perceptions of cannabis products
Kogan LR, Hellyer PW, Silcox S et al. · Can Vet J · Year 2019 · Species: Dog
View on PubMed →Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
Lafuente H, Pazos MR, Alvarez A et al. · Front Neurosci · Year 2016 · Species: Pig
View on PubMed →Evaluation of Δ(9)-tetrahydrocannabinol metabolites and oxidative stress in type 2 diabetic rats
Coskun ZM, Bolkent S. · Iran J Basic Med Sci · Year 2016 · Species: Cat, Rat
View on PubMed →
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